When one talk about science blogs, one cannot get around Pharyngula, which is the flagship blog of the ScienceBlogs, at least when you look at the sheer amount of traffic.
It's run by Dr. P.Z. Myers, a biologist and assistant professor at the University of Minnesota, Morris. Myers is a vocal atheist, and is often more known for this aspect of his blogging, but he is also a prolific blogger on the subject of science, though it might not appear so, since the science posts might drown in the sheer amount of blogging he does.
On the front of skepticism, PZ Myers focuses on debunking claims by creationists and the intelligent design crowd, especially those made by the Discovery Institute.
The comment section of Pharyngula is rowdy, and not for the faint-at-heart, but many of the regular commenters are highly knowledgeable on their fields, and it can be a learning experience to read through the comment section, when a scientific conversation is happening.
The finest moment of the Pharyngula commenters was probably when they uncovered plagiarism in a peer-reviewed paper, which seemed to be advocating creationism (a full description of this incident can be found here: Creationism Slips Into a Peer-Reviewed Journal)
Related links:
Pharyngula archives - the content of the original Pharyngula blog, before it moved to ScienceBlogs
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