The Skeptic Zone

The Skeptic Zone is the podcast from the Australian Skeptics

The history of the podcast is a bit confusing, and I am probably going to explain it wrong, but I'll try. It started out as an internet radio show in 2001 called The Skeptic Tank. This ran until 2002.
In 2005, The Skeptic Tank was revived, and it 2006 it changed its name to The Tank Podcast, before it was turned into a vodcast in 2007, named The Tank Vodcast. Finally, in 2008 it returned to the podcast format, this time under the current name of The Skeptic Zone.

The show tend to comment on current events related to skepticism and the episodes often contains interviews with prominent skeptics from around the world. It also has regular segments such as Dr Rachie Reports, where Dr Rachael Dunlop goes into alternative medicine.

Skepticality

Skepticality is the official podcast of the Skeptic Magazine. Hosted by Derek Colanduno and Swoopy.

The podcasts covers current events (from a skeptical point of view) as well as subjects within skepticism. They also have guests on the shows - these guests are often prominent skeptics or scientists.

Skeptoid

Skeptoid is a podcast made by Brian Dunning. The easiest way to introduce Skeptoid is to quote the description on the website

Skeptoid is a weekly science podcast dedicated to furthering knowledge by blasting away the widespread pseudosciences that infect popular culture.

Each weekly episode focuses on a single phenomenon — an urban legend, a paranormal claim, alternative therapy, or something just plain stupid — that you've heard of, and that you probably believe in. Skeptoid attempts to expose the folly of belief in non-evidence based phenomena, and more importantly, explains the factual scientific reality.

The show started in October, 2006, and there is currently 179 episodes, with a new one added each week.

The Skeptics' Guide to the Universe

The Skeptics Guide to the Universe is a weekly Science podcast produced by the New England Skeptical Society (NESS) in association with the James Randi Educational Foundation (JREF) : discussing the latest news and topics from the world of the paranormal, fringe science, and controversial claims from a scientific point of view.

This is the description of The Skeptics' Guide to the Universe at their website. While correct, it doesn't quite do it justice. The contributors have an impressive knowledge about the skeptic subjects that the cover in the podcast, and they often have interviews with some of the major voices in skepticism.

Sundays Supplement

Strictly speaking, the Sundays Supplement podcast is not dedicated to neither skepticism nor science, but rather to a humorous take on the supplements in British Sunday newspapers.

The podcast is, however, run by two comics - Simon Dunn and Iszi Lawrence, who are also skeptics, and who will merciless mock any woo or quackery they find in the newspapers.

The show also frequently has guests appearing, such as Rebecca Watson of Skepchick and Richard Wiseman.

So, if you like British humor with a touch of skepticism added, Sundays Supplement is well worth your listen.